When to switch for antiretroviral treatment failure in resource-limited settings?
نویسندگان
چکیده
Thanks to the leadership of the World Health Organisation (WHO) [1], and massive financial support from programmes such as the Global Fund and the US President’s Emergency Plan for AIDS Relief (PEPFAR), the number of HIV-infected individuals accessing antiretroviral therapy (ART) in resource-limited settings has tripled from 2001 to 2005. An estimated 1.3 million HIV-infected individuals were on ART in 2005, representing 20% of those in need of treatment [2].
منابع مشابه
The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings.
WHO has proposed a public-health approach to antiretroviral therapy (ART) to enable scaling-up access to treatment for HIV-positive people in developing countries, recognising that the western model of specialist physician management and advanced laboratory monitoring is not feasible in resource-poor settings. In this approach, standardised simplified treatment protocols and decentralised servi...
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BACKGROUND A growing proportion of patients on antiretroviral therapy in resource-limited settings have switched to second-line regimens. We carried out a systematic review in order to summarize reported rates and reasons for virological failure among people on second-line therapy in resource-limited settings. METHODS Two reviewers independently searched four databases and three conference we...
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The delay between first-line antiretroviral therapy (ART) failure and initiation of second-line ART in resource-limited settings can be prolonged. Increasing evidence links delayed antiretroviral switch with increased risk for opportunistic infection (OI) and death, particularly in patients with advanced HIV at the time of first-line failure. As access to viral load (VL) monitoring widens beyon...
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When antiretroviral therapy (ART) scale up began in Africa a decade ago, there was concern that lack of laboratory monitoring for patients receiving antiretroviral drugs would be an obstacle to providing treatment. To address this concern, the first set of World Health Organization (WHO) guidelines for ART in resource-limited settings rightly recommended that programmes should primarily use cli...
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ورودعنوان ژورنال:
- AIDS
دوره 21 9 شماره
صفحات -
تاریخ انتشار 2007